Association Between Estimated Glomerular Filtration Rate And Serum Sodium Levels In Patients With Chronic Kidney Disease On Pre-Dialysis

Abstract

Chronic Kidney Disease (CKD) is a progressive disease characterized by nephron damage and a decrease in glomerular filtration rate. Decreased kidney function can disrupt fluid and electrolyte homeostasis, including serum sodium levels. This study aimed to analyze the relationship between GFR and serum sodium levels in pre-dialysis CKD patients at RSI Sakinah Mojokerto. This was a quantitative study with a correlational analytical design and a retrospective approach. The population consisted of 215 pre-dialysis CKD patients, with a sample of 80 respondents selected using purposive sampling. GFR data were calculated using the CKD-EPI formula based on creatinine levels, and serum sodium levels were obtained from medical records. Analysis was performed using Spearman’s Rho test with α < 0.05. The majority of respondents were in Stage 4 of renal function decline, totaling 57 individuals (71.25%). Most experienced hypernatremia, totaling 65 individuals (81.25%), while hyponatremia was found in 5 individuals (6.25%). Spearman’s Rho test showed a p-value of 0.022 with a correlation coefficient of r = 0.255, indicating a significant association with a weak correlation between GFR and serum sodium levels. Monitoring of LFG and serum sodium levels should be performed routinely to evaluate disease progression, detect electrolyte disturbances early, and help prevent complications in pre-dialysis CKD patients.